Bexarotene
C24H28O2
348.49
4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid;
4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)vinyl]benzoic acid [153559-49-0]
4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid;
4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)vinyl]benzoic acid [153559-49-0]
BRIEFING
Bexarotene. Because there is no existing USP monograph for this drug substance, a new monograph based on validated methods of analysis is proposed. The liquid chromatographic procedures in the Assay and the test for Organic Impurities were validated using the Symmetry C8 brand of column with L7 packing. The typical retention time for bexarotene is about 9 min.
Description and solubility information: White to off-white powder. Slightly soluble in vegetable oil and in ethanol; insoluble in water.
(SM3: J. Li)
Correspondence Number—C305491