INTRODUCTION

Ion chromatography (IC) is a high-performance liquid chromatography (HPLC) instrumental technique used in USP test procedures such as identification tests, assays, and determination of impurities, including limit test and quantitative tests. IC is used to measure anions and cations derived from organic or inorganic molecules, from small molecules to larger biomolecules. This may include, but is not limited to, organic acids, carbohydrates, sugar alcohols, aminoglycosides, amino acids, amines, phosphonates, peptides, aminoglycosides, oligosaccharides, proteins, and glycoproteins.