4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-, 4,4-dioxide, sodium salt, [2S-(2α,3β,5α)]-;
Sodium (2S,3S,5R)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide [89785-84-2]
BRIEFING
Tazobactam Sodium. Because there is no existing USP monograph for this drug substance, a new monograph based on validated methods of analysis is proposed.
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The liquid chromatographic procedure used in the Assay is based on validation performed using the Inertsil ODS-3 C18 brand of column with L1 packing. The typical retention time for tazobactam is about 7 min.
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The liquid chromatographic procedure used in the Organic Impurities test is based on validation performed using the XBridge C18 brand of column with L1 packing. The typical retention time for tazobactam is about 12 min.
Description and Solubility information: White or off-white powder. Very soluble in water; soluble in alcohol; insoluble in ethyl acetate.
(SM1: P. Pabba, C. Hiemer)
Correspondence Number—C132775