Cyclopropanecarboxylic acid, 3-(2,2-dichloroethenyl)-2,2-dimethyl-, (3-phenoxyphenyl)methyl ester;
(±)-3-Phenoxybenzyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate [52645-53-1]
BRIEFING
Permethrin. Because there is no existing USP monograph for this drug substance, a new monograph based on validated methods of analysis is proposed.
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The liquid chromatographic procedure in the Assay was validated using the Spherisorb Silica brand of column with L3 packing. The typical retention times for cis isomers and trans isomers of permethrin are about 6 and 7.6 min, respectively.
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The gas chromatographic procedure used in the Organic Impurities test was validated using the Zebron ZB-1 brand of column with phase G1. The typical retention time for permethrin is about 23 min.
Description and solubility information: Colorless to slightly brownish viscous liquid, semi-solid or crystalline solid. The appearance depends on the ratio of isomers. Very soluble in n-heptane; freely soluble in anhydrous ethanol; practically insoluble in water .
(SM3: T. Devarshi)
Correspondence Number—C228297