Trypsin inhibitor, pancreatic basic;
l-Arginyl-l-prolyl-l-aspartyl-l-phenylalanyl-l-cysteinyl-l-leucyl-l-glutamyl-l-prolyl-l-prolyl-l-tyrosyl-l-threonylglycyl-l-prolyl-l-cysteinyl-l-lysyl-l-alanyl-l-arginyl-l-isoleucyl-l-isoleucyl-l-arginyl-l-tyrosyl-l-phenylalanyl-l-tyrosyl-l-asparaginyl-l-alanyl-l-lysyl-l-alanylglycyl-l-leucyl-l-cysteinyl-l-glutaminyl-l-threonyl-l-phenylalanyl-l-valyl-l-tyrosylglycylglycyl-l-cysteinyl-l-arginyl-l-alanyl-l-lysyl-l-arginyl-l-asparaginyl-l-asparaginyl-l-phenylalanyl-l-lysyl-l-seryl-l-alanyl-l-glutamyl-l-aspartyl-l-cysteinyl-l-methionyl-l-arginyl-l-threonyl-l-cysteinylglycylglycyl-l-alanine cyclic (5→55), (14→38), (30→51) tris(disulfide) [9087-70-1]
DEFINITION
Aprotinin is a polypeptide consisting of a chain of 58 amino acid residues, which inhibits stoichiometrically the activity of several proteolytic enzymes such as chymotrypsin, kallikrein, plasmin, and trypsin. Aprotinin is obtained from bovine tissues and purified by a suitable process, and is stored as a bulk solution or lyophilized powder. Its potency, calculated on the dried basis, is NLT 3 USP Aprotinin Units/mg. In addition, the method of manufacture is validated to result in NMT 0.2 µg of histamine per 3 USP Aprotinin Units using validated methods. The origin and sourcing of bovine material must be specified in compliance with FDA requirements. The manufacturing process is validated to demonstrate the clearance of potential infectious agents (i.e., viruses, TSE agents). One USP Aprotinin Unit is equivalent to 1800 Kallikrein Inhibition Units (K.I.U.).
USP REFERENCE STANDARDS FOR PURCHASE
USP Aprotinin RSUSP Aprotinin System Suitability RS
USP Trypsin Crystallized RS