DEFINITION

Construct Human Fibroblasts in Bilayer Synthetic Scaffold is a nonliving monolayer skin substitute derived from neonatal foreskins. It is composed of fibroblasts, an extracellular matrix, and a nylon mesh bonded to a transparent, semi-permeable silicone membrane. Human fibroblasts are seeded onto the nylon mesh. The fibroblasts proliferate within the nylon mesh and secrete human matrix proteins. Following freezing, no cellular metabolic activity remains.