BRIEFING

 Amitriptyline Compounded Oral Suspension. Because there is no existing USP monograph for this compounded preparation, a new monograph based on a validated stability-indicating method is being proposed. The liquid chromatographic procedure in the Assay is based on analyses validated using the Xbridge C18 brand of analytical column with L1 packing. The typical retention time for Amitriptyline Hydrochloride is about 3.2 min.

 Please submit comments to CompoundingSL@usp.org.

 (CMP: B. Groat)

 Correspondence Number—C325492