BRIEFING

 〈1243〉 Wetting Properties of Pharmaceutical Systems. In the framework of the pharmaceutical continuous manufacturing processes, this new general chapter was developed to provide guidelines for the evaluation of wetting properties of pharmaceutical systems. The wetting properties of pharmaceutical systems are important in batch and continuous manufacturing, formulations, and final product quality. Therefore, the USP General Chapters–Physical Analysis Expert Committee is proposing this new general chapter to address the needs of the pharmaceutical industry for the standardization of the analytical technology used in characterization of wetting properties. The chapter covers the following topics:

• Background on wetting properties

• Applications of wetting properties

• Approaches to improve or modify wetting properties

• Relevance of surface tension of liquids in wetting properties

• Liquid surface tension measurement techniques

• Factors affecting liquid surface tension

• Assessment of wetting properties by contact angle

• Contact angle measurement techniques

• Factors affecting contact angle

• Relevance of surface free energy of solids

• Solid surface free energy measurement techniques

 (GCPA: A. Hernandez-Cardoso)

 Correspondence Number— C322777