BRIEFING

 〈1762〉 Solid-State Nuclear Magnetic Resonance Spectroscopy—Theory and Practice. The solid-state nuclear magnetic resonance (ssNMR) spectroscopy differs from solution NMR spectroscopy in that it focuses on issues directly related to the solid-state properties of materials. These include crystalline form, solid dosage forms, and stability in the solid state. Previously, the discussion of ssNMR spectroscopy was located in Applications of Nuclear Magnetic Resonance Spectroscopy 〈1761〉 on NMR spectroscopy. However, the applications of ssNMR have grown to the point where a general chapter that focuses on ssNMR spectroscopy is warranted. Therefore, the Chemical Analysis Expert Committee is proposing the following new informational general chapter about ssNMR spectroscopy. The aim of this new chapter is to discuss the fundamental principles and practical applications of ssNMR spectroscopy in pharmaceutical systems. It is written for pharmaceutical scientists who characterize materials in the solid state.

 This new chapter provides an overview of key aspects of ssNMR spectroscopy:

1. Covers essential theory, essential line-narrowing, and signal enhancement techniques such as high-power ¹H decoupling, magic-angle spinning (MAS), and cross-polarization, along with additional advanced methods such as ultrafast MAS, dynamic nuclear polarization, and two-dimensional techniques.

2. Introduces best practices for acquiring ssNMR spectra, including instrument setup, sample preparation, data processing, and spectral quality considerations.

3. Showcases the wide-ranging applications of ssNMR spectroscopy, including physical form characterization, components quantitation, and ssNMR relaxation and crystallography.

 (GCCA: Y. Liu)

 Correspondence Number—C311897