Scopolamine
C17H21NO4
303.36
Benzeneacetic acid, α-(hydroxymethyl)-, (1α,2β,4β,5α,7β)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester, (αS)-;
(1R,2R,4S,5S,7s)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-yl (S)-3-hydroxy-2-phenylpropanoate [51-34-3]
Benzeneacetic acid, α-(hydroxymethyl)-, (1α,2β,4β,5α,7β)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester, (αS)-;
(1R,2R,4S,5S,7s)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-yl (S)-3-hydroxy-2-phenylpropanoate [51-34-3]
BRIEFING
Scopolamine. Because there is no existing USP monograph for this drug substance, a new monograph based on validated methods of analysis is proposed.
The liquid chromatographic procedure in the test for Organic Impurities was validated using the Symmetry C18 brand of column with L1 packing. The typical retention time for scopolamine is about 10 min.
Description and solubility information: White or almost white crystalline powder or colorless crystal. Freely soluble in alcohol; soluble in water.
(SM3: L. Lasker)
Case ID—SUB-1922