DEFINITION

Coptis Species Rhizome Dry Extract is prepared from the dried rhizome of Coptis species (Coptis chinensis Franch., Coptis deltoidea C.Y.Cheng & P.K.Hsiao, or Coptis teeta Wall.) by extraction with water or hydroalcoholic mixtures. It contains NLT 90% and NMT 110% of the labeled amount of total quaternary protoberberine alkaloids calculated as the sum of columbamine (C₂₀H₂₀NO₄⁺), jatrorrhizine (C₂₀H₂₀NO₄⁺), epiberberine (C₂₀H₁₈NO₄⁺), coptisine (C₁₉H₁₄NO₄⁺), palmatine (C₂₁H₂₂NO₄⁺), and berberine (C₂₀H₁₈NO₄⁺) on the dried basis. The berberine content is about 50% or above 50% of the total quaternary protoberberine alkaloids content calculated on the dried basis. It may contain suitable added substances as carriers.