DEFINITION

Bitter Orange Fruit Flavonoids Dry Extract is prepared from the unripe fruit of Citrus × aurantium L. (Family Rutaceae) by extraction with hydroalcoholic mixtures. It contains NLT 45% of total citrus flavonoids on the dried basis, calculated as the sum of eriocitrin (C₂₇H₃₂O₁₅), neoeriocitrin (C₂₇H₃₂O₁₅), isonaringin (C₂₇H₃₂O₁₄), naringin (C₂₇H₃₂O₁₄), hesperidin (C₂₈H₃₄O₁₅), neohesperidin (C₂₈H₃₄O₁₅), rhoifolin (C₂₇H₃₀O₁₄), diosmin (C₂₈H₃₂O₁₅), neodiosmin (C₂₈H₃₂O₁₅), naringenin (C₁₅H₁₂O₅), didymin (C₂₈H₃₄O₁₄), hesperetin (C₁₆H₁₄O₆)–poncirin (C₂₈H₃₄O₁₄) (coelution), and other unspecified flavonoids. It also contains NLT 20% of naringin, NLT 10% of neohesperidin, and NMT 2.5% of hesperidin. The content ratio of naringin to neohesperidin is between 2:1 and 1:1. The content of unspecified flavonoids is NMT 4%.